Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice
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منابع مشابه
Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice.
Congenic mouse strains VM/Dk and VM-Sincs7/Dk differ at the Sinc gene, which controls the incubation period of scrapie in mice; VM/Dk mice are Sincp7p7 and VM-Sincs7/Dk mice are Sincs7s7. Restriction fragment length polymorphism and DNA sequencing analysis demonstrated that the PrP genes also differ in these strains, confirming the close genetic linkage of Sinc and PrP. Using the restriction en...
متن کاملPrP knock-out and PrP transgenic mice in prion research.
Spongiform encephalopathies such as scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle or Creutzfeldt-Jacob disease (CJD) and Gerstmann-Sträussler-Scheinker syndrome (GSS) in humans is caused by a transmissible agent designated prion. The 'protein only' hypothesis proposes that the prion consists partly or entirely of a conformational isoform of the normal host protein PrP(C), d...
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Error estimates with explicit constants are given for approximations of functions, definite integrals and indefinite integrals by means of the Sinc approximation. Although in the literature various estimates have already been given for these approximations, they were basically for examining the rates of convergence, and several constants were left unevaluated. Giving more explicit estimates, i....
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Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp (-/-)) mice. So far, six types of Prnp (-/-) mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obta...
متن کاملHelices 2 and 3 are the initiation sites in the PrP(C) → PrP(SC) transition.
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form, PrP(C), undergoes in its conversion to a self-replicating state is still not fully understood. The ordered C-terminus of PrP(C) proteins has three helices (H1-H3). Here, we use statistical coupling analysis (...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1992
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-73-10-2751